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11.
Back Cover: Lipopeptide Nanoparticles: Development of Vaccines against Hookworm Parasite (ChemMedChem 10/2015) 下载免费PDF全文
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We present a new hydrodynamic modelling framework capable of fully exploiting modern graphics and central processing units (GPUs and CPUs) from any of the mainstream vendors, to be used in the design and assessment of sustainable drainage systems. A finite-volume Godunov-type scheme is combined with the HLLC Riemann solver to create a robust numerical model which correctly addresses wetting and drying and transient flow conditions, and is suitable for application to a wide range of flood simulations. The software is tested with a three day flood event in Carlisle during 2005, at resolutions from 25 m to 2 m. Run-times are significantly reduced without compromising numerical accuracy. Excellent agreement is found between the simulation results and a comprehensive post-event survey. Changes in sensitivity to Manning's n are examined at different resolutions, with changes to the floodplain found to have little influence at 2 m resolution. 相似文献
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Biological materials exhibit anisotropic characteristics because of the anisometric nature of their constituents and their preferred alignment within interfacial matrices. The regulation of structural orientations is the basis for material designs in nature and may offer inspiration for man‐made materials. Here, how structural orientation and anisotropy are designed into biological materials to achieve diverse functionalities is revisited. The orientation dependencies of differing mechanical properties are introduced based on a 2D composite model with wood and bone as examples; as such, anisotropic architectures and their roles in property optimization in biological systems are elucidated. Biological structural orientations are designed to achieve extrinsic toughening via complicated cracking paths, robust and releasable adhesion from anisotropic contact, programmable dynamic response by controlled expansion, enhanced contact damage resistance from varying orientations, and simultaneous optimization of multiple properties by adaptive structural reorientation. The underlying mechanics and material‐design principles that could be reproduced in man‐made systems are highlighted. Finally, the potential and challenges in developing a better understanding to implement such natural designs of structural orientation and anisotropy are discussed in light of current advances. The translation of these biological design principles can promote the creation of new synthetic materials with unprecedented properties and functionalities. 相似文献
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Nabil Magbool Jan Biao Huang Aris Espejo Luke Zelmer Fangwei Xu Lee Gulbransen 《加拿大化工杂志》2020,98(10):2125-2136
For the mining based oilsands industry, it is desirable to determine the quality of the ore delivered to the extraction processes in real-time to make optimal operational decisions such as optimal ore blending to achieve maximal bitumen recovery. Currently, the industry determines the real-time ore characteristics for any given shovel Global Positioning System (GPS) location by first determining the shovel elevation from the topological mine map and then using the determined geological coordinates in the 3D geological block model. It should be noted that the block model is built based on the widely spaced core hole samples, and it is updated only on a yearly basis due to high cost of narrower core hole sampling. Thus, the block model predictions are often inaccurate in between the core hole spacing. On the other hand, mining operations data are available that contain accurate ore characteristics information in the already mined area. Therefore, in this work, we present a just-in-time based data-driven modelling strategy that utilizes the recently available mining operations data to obtain reliable ore characteristics given the GPS data. The prediction capability of ore characteristics using the proposed modelling strategy is validated at core hole locations. Further, the prediction of ore characteristics at non-core hole points demonstrate promising results. 相似文献
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Thomas L. Bougher Luke Yates Chien-Fong Lo Wayne Johnson 《Nanoscale and Microscale Thermophysical Engineering》2016,20(1):22-32
In this work, we investigate the thermal boundary resistance and thermal conductivity of GaN layers grown on Si with 100 nm AlN transition layers using time domain thermoreflectance (TDTR). The GaN layers ranged from 0.31 to 1.27 μm. Due to the challenges in determining the thermal boundary resistance of the buried interfaces found in this architecture, a new data reduction scheme for TDTR that utilizes a Monte Carlo fitting method is introduced and found to dramatically reduce the uncertainty in certain model parameters. The results show that the GaN thermal conductivity does not change significantly with layer thickness, whereas the resistance of the AlN layer decreases slightly with GaN thickness. 相似文献
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Beladenta Amalia Marcela Fu Olena Tigova Montse Ballbè Yolanda Castellano Sean Semple Luke Clancy Constantine Vardavas Maria J. López Nuria Cortés Raúl Pérez-Ortuño José A. Pascual Esteve Fernández 《Indoor air》2021,31(5):1601-1613
Secondhand electronic cigarette (e-cigarette) aerosol (SHA) might impair indoor air quality and expose bystanders. This study aims to investigate exposure to SHA in controlled conditions of enclosed settings simulating real-world scenario. An experiment was performed in a car and in a room, in which SHA was generated during a 30-minute ad libitum use of an e-cigarette. The experiment was replicated on five consecutive days in each setting. We measured PM2.5, airborne nicotine concentrations, and biomarkers of exposure to SHA, such as nicotine metabolites, tobacco-specific nitrosamines, propylene glycol, and glycerol in bystanders’ saliva samples before, during, and after the exposure period. Self-reported health symptoms related to exposure to SHA were also recorded. The results showed that the highest median PM2.5 concentration was recorded during the exposure period, being 21 µg/m3 in the room setting and 16 µg/m3 in the car setting—about twofold increase compared to the baseline. Most concentrations of the airborne nicotine and all biomarkers were below the limit of quantification in both settings. Bystanders in both settings experienced some short-term irritation symptoms, expressed as dry throat, nose, eyes, and phlegm. In conclusion, short-term use of an e-cigarette in confined spaces increased indoor PM2.5 level and caused some irritation symptoms in bystanders. 相似文献
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John A. Killion Sharon Kehoe Luke M. Geever Declan M. Devine Eoin Sheehan Daniel Boyd Clement L. Higginbotham 《Materials science & engineering. C, Materials for biological applications》2013,33(7):4203-4212
Due to the deficiencies of current commercially available biological bone grafts, alternative bone graft substitutes have come to the forefront of tissue engineering in recent times. The main challenge for scientists in manufacturing bone graft substitutes is to obtain a scaffold that has sufficient mechanical strength and bioactive properties to promote formation of new tissue. The ability to synthesise hydrogel based composite scaffolds using photopolymerisation has been demonstrated in this study. The prepared hydrogel based composites were characterised using techniques including Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), Energy-dispersive X-ray spectrometry (EDX), rheological studies and compression testing. In addition, gel fraction, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), porosity and swelling studies of the composites were carried out. It was found that these novel hydrogel bioglass composite formulations did not display the inherent brittleness that is typically associated with bioactive glass based bone graft materials and exhibited enhanced biomechanical properties compared to the polyethylene glycol hydrogel scaffolds along. Together, the combination of enhanced mechanical properties and the deposition of apatite on the surface of these hydrogel based composites make them an ideal candidate as bone graft substitutes in cancellous bone defects or low load bearing applications. 相似文献